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pentobarbital will reduce the level or impact of prednisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.pentobarbital increases effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Keep an eye on. Coadministration of ifosfamide with CYP2B6 inducers may well raise metabolism of ifo